Organocatalytic enantioselective conjugate addition of ketones to isatylidine malononitriles.
نویسندگان
چکیده
An enantioselective Michael addition of ketones to alkylidenemalononitriles catalyzed by chiral primary amine I with (R)-5c as a co-catalyst in good yields (>90%) and with good enantioselectivities (85-96% ee) has been developed. The strategy has also been extended to a three-component version through a domino Knoevenagel/Michael sequence with similar or better outcomes.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 11 شماره
صفحات -
تاریخ انتشار 2012